Epilepsy and Psychiatric Comorbidities: Drug Selection.

Purpose of review The pharmacological treatment of patients with epilepsy and psychiatric comorbidities may sometimes represent a therapeutic challenge. This review is focused on the pharmacological management of patients with epilepsy and psychiatric problems in terms of rationalization of the antiepileptic drug (AED) treatment and the pharmacological management of the most clinically relevant psychiatric comorbidities, namely mood and anxiety disorders, psychoses, and attention deficit hyperactivity disorder (ADHD). Recent findings Up to 8% of patients with drug-resistant epilepsy develop treatment-emergent psychiatric adverse events of AED regardless of the mechanism of action of the drug and this is usually related to an underlying predisposition given by the previous psychiatric history and the involvement of mesolimbic structures. Careful history taking, periodic screening for mood and anxiety disorders, low starting doses, and slow titration schedules can reduce the possibility of AED-related problems. A pragmatic checklist for the pharmacological management of patients with epilepsy and psychiatric disorders is presented. Summary patients should be informed of potential behavioral effects of AEDs but no drugs should be excluded a priori. Any psychiatric comorbidity should be addressed in the appropriate setting and full remission and recovery should always represent the first goal of any therapeutic intervention. Neurologists should be aware of the side effects of major psychotropic drug classes in order to fully counsel their patients and other health professionals involved

Frecuencia cardiaca, formas de organización y situaciones de juego en baloncesto

Introduction: The purpose of this study was to find out the effect of task organization and different game situations on intensity and of repetitions in basketball. Method: A quasi-experimental design with twelve players group of 12, 4 ± 0, 7 years-old average was done. Three training sessions about lay-up was realized. The independent variables were task organization and different game situations. The dependent variables were heart rate and number of repetitions, and player´s perception about intensity and work. Results: a) statistically significant differences in heart rate between the status of 1x0 and 2x2 (p =. 014), and trends towards significance between the situation of game 1x0 and 3x3 (p =. 065), b) were statistically significant differences in heart rate between the situation frequents gaming 1x0 circuit on the rows (p =. 027) and forms involving simultaneous moves (p =. 000), and the game situation 1x1 between rows with respect to the ways games with simultaneous participation (p =. 014); c) The effect of the interaction between the game situation factor and type of organization was statistically significant (F6, 42 = 9,256, p =. 000 ). Are statistically significant differences in the number of operations performed by the players on the combination of the four game situations and the three types of organization. Conclusions: a) The groups in circuits had a greater number of repetitions and intensity perceived, b) the groups in games through forms showed greater heart rate and more repetitions, and c) the group in rows presented no value to excel regard to the task structure. From the collected data, it is deduced that depending on which are the objectives of the sports abilities, will be more useful adapted to use a type of organization or another one.Introducción: El presente trabajo analiza la influencia de diferentes formas de organización y situaciones de juego sobre la intensidad y el número de intervenciones en baloncesto. Método: Se realizó un diseño cuasi-experimental, con 12 jugadores de edad 12,4 ± 0,7, años. Se realizaron tres sesiones de intervención sobre el lanzamiento a canasta en carrera (entrada a canasta). Las variables independientes fueron la forma de organización y las diferentes situaciones de juego. Las variables dependientes fueron la frecuencia cardiaca media, el número de intervenciones de lanzamientos, y la percepción de la intensidad de trabajo de los jugadores. Resultados: a) se observan diferencias estadísticamente significativas en frecuencia cardiaca entre la situación de 1x0 y la de 2x2 (p=.014), y tendencias a la significación entre la situación de juego de 1x0 y la de 3x3 (p=.065), b) Se aprecian diferencias estadísticamente significativas en frecuenta cardiaca entre la situación de juego de 1x0 en circuito con respecto a las filas (p=.027) y las formas jugadas con participación simultanea (p=.000), y en la situación de juego de 1x1 entre filas con respecto a las formas jugadas con participación simultanea (p=.014); c) El efecto de la interacción entre el factor situación de juego y tipo de organización fue estadísticamente significativo (F6,42 = 9.256, p=.000). Se aprecian diferencias estadísticamente significativas en el número de intervenciones realizadas por los jugadores en la combinación de las cuatro situaciones de juego y los tres tipos de organización. Conclusiones: a) La organización grupal con participación simultánea mediante circuitos presentó mayor número de intervenciones e intensidad percibida; b) la organización grupal con participación simultánea mediante formas jugadas con participación simultanea mostró mayor frecuencia cardiaca y más intervenciones; y c) la organización grupal con participación alternativa mediante filas no presentó ningún valor que sobresalga respecto a las formas de organización. A partir de los datos obtenidos, se deduce que dependiendo de cuáles sean los objetivos de la habilidad deportiva, será más adecuado utilizar un tipo de organización u otro

The Mediational Role of Desire for Cultural Tightness on Concern With COVID-19 and Perceived Self-Control

When ecological threats are more severe or prevalent, societies are more likely to tighten their social norms and punishments. Moreover, when people follow clear and tight rules, they are more prone to regulate their behavior (i.e., self-control) in order to avoid punishment. Therefore, we examined the mediating role of people’s endorsement of cultural tightness (i.e., support and desire) on the relationship between concern with COVID-19 threat and personal self-control. Our hypothesis was tested through a mediation model in two studies with a sample of (N=315, 77.1% females, Mage=23.71) university students (Study 1) and with a heterogeneous sample of (N=239, 65.7% females, Mage=36.55) participants (Study 2). Empirical support for the proposed model was found in both studies. Implications of this research will be discussed. The main implication is related to the possibility that people’s desire for strong norms to cope with the COVID-19 threat could promote greater self-regulated preventive behavior in order to protect their health

Nutrition, bioenergetics, and metabolic syndrome

According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world's population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden

Relationship between antioxidant capacity and angiotensin-converting enzyme inhibitory activity of papain-generated protein hydrolysates and peptides from palm kernel cake proteins

Palm kernel cake (PKC) proteins were hydrolysed in the presence of seven proteolytic enzymes. The antioxidant and antihypertensive activities of each protein hydrolysate were evaluated. Papain-generated protein hydrolysate showed the highest antioxidant effects measured by radical scavenging activity (65%), iron (Fe)(II)-chelating activity (65%), and antihypertensive activity (71%). The results revealed a strong correlation between the antioxidant activity of the protein hydrolysates with angiotensin-converting enzyme (ACE) inhibitory activity (R2 = 0.69 - 0.98), except for trypsin-generated hydrolysate (R2= 0.22). The most potent protein hydrolysate was fractionated and profiled using reversed-phase high-performance liquid chromatography and isoelectric focusing; peptides were subsequently isolated and identified by tandem mass spectrometry. The individual peptides were evaluated for antihypertension potential. A positive correlation was identified between radical scavenging activity and Fe(II)-chelating activity together and ACE inhibitory activity with R2 = 0.69 - 0.98. The findings indicate that there was a positive relationship between the antioxidant and antihypertensive activities of protein hydrolysates and bioactive peptides from PKC proteins

Accounting Information Systems [1st Australasian edition]

At last – the Australasian edition of Romney and Steinbart's respected AIS text! Accounting Information Systems first Australasian edition offers the most comprehensive and student-friendly coverage of Accounting Information Systems in Australia, New Zealand and Asia. Accounting Information Systems has been extensively revised and updated to incorporate local laws, standards and business practices. The text has a new and flexible structure developed especially for Australasian AIS courses, while also retaining the features that make the US edition easy to use. Important concepts such as systems cycles, controls, auditing, fraud and cybercrime, ethics and the REA data model are brought to life by a wide variety of Australasian case studies and examples. With a learning and teaching resource package second to none, this is the perfect resource for one-semester undergraduate and graduate courses in Accounting Information Systems

A decision support system for modelling and implementing the supply network configuration and operations scheduling problem in the machine tool industry

[EN] This paper presents a decision support system to simultaneously solve the supply network configuration problem and the operations scheduling problem for the machine tool industry. A novel database structure, which is able to consider alternative operations and alternative bills of material, has been used. An algorithm for complete enumeration to determine all the feasible solutions using stroke graphs is introduced. A multiagent-based simulator evaluates the different key performance indicators that the supply network deals with for each alternative solution (e.g. workload, profits, delivery times, etc.) to determine that ‘satisficed’ by the collaborative decision-making among its members. A case study based on a Spanish company that assembles highly customised machines and tools in several European plants is considered. From the experiments results based on data linked to this industry, it will be demonstrated that the tool is potentially useful for stakeholders and for the central decision-maker to make decisions collaboratively in a multisite context caseWe thank the EWG-DSS and their four expert anonymous referees as well as the guest editorial board for their useful suggestions and criticism on earlier versions of this paper. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. NMP2-SL-2009-229333 and has been partially supported by the Spanish Ministry of Science and Innovation within the 'Proyectos de Investigacion Fundamental No Orientada Programme' through Project 'CORSARI MAGIC DPI2010-18243'. Julien Maheut holds a VALi+d grant funded by the Regional Valencian Government (Ref. ACIF/2010/222).Maheut, JPD.; Besga, JM.; Uribetxebarria, J.; García Sabater, JP. (2014). A decision support system for modelling and implementing the supply network configuration and operations scheduling problem in the machine tool industry. Production Planning and Control. 25(8):679-697. https://doi.org/10.1080/09537287.2013.798087S67969725

Polyamines as an ecofriendly postharvest tool to maintain fruit quality

Polyamines (PAs) are natural compounds involved in a wide range of plant growth and developmental process, such as cell division, dormancy breaking, germination, development of flower buds, fruit set, growth and ripening, as well as in plant responses to environmental stresses including chilling injury. This chapter will focus on the role of PAs in fruit growth and ripening, with special emphasis on the effects of pre- and postharvest PA treatment on fruit quality attributes, bioactive constituents with antioxidant activity, and tolerance of fruit to chilling injury damage. The results of this chapter provide evidence for the numerous beneficial effects of the exogenous PA treatments, both at pre- and postharvest time in fruit quality attributes including their concentration in antioxidant compounds. Taking into account that PAs are naturally occurring molecules their application as pre- or postharvest treatment could be considered as an environmentally compatible tool as they can be metabolized by fruit cells. In addition, it should be pointed out that although exogenous application of PAs enhances their endogenous levels, the concentrations remain far lower than the toxic ones. Since modern agriculture is searching for effective biological molecules with well-known metabolic effects but without toxicological effects, a possible answer may be related to PA treatments

A Parallelizable Heuristic for Solving the Generic Materials and Operations Planning in a Supply Chain Network: A Case Study from the Automotive Industry

[EN] A trend in up-to date developments in multi-site operations planning models is to consider in details the different ways to produce, buy or transport products and the distributed decision-making process for operations planning. One of the most generic approaches to support global optimization in those supply chain networks by considering all the different operations alternatives and product structures is the Generic Materials & Operations Planning Problem. This problem can be modelled by a Mixed Integer Linear Programming model capable of considering production, transportation, procurement tasks and their alternatives and other relevant issues such as packaging. The aim of this paper is to introduce the implementation of a parallelizable heuristic method for materials and operations planning and its application to a case of a Supply Chain Network of the automotive industry. The approach uses variants of the GMOP model to overcome traditional MRP systems' limitations.Maheut ., JP.; García Sabater, JP. (2013). A Parallelizable Heuristic for Solving the Generic Materials and Operations Planning in a Supply Chain Network: A Case Study from the Automotive Industry. IFIP Advances in Information and Communication Technology. 397:151-157. doi:10.1007/978-3-642-40352-1_20S151157397Maheut, J., Garcia-Sabater, J.P.: La Matriz de Operaciones y Materiales y la Matriz de Operaciones y Recursos, un nuevo enfoque para resolver el problema GMOP basado en el concepto del Stroke. Dirección y Organización 45, 46–57 (2011)Garcia-Sabater, J.P., Maheut, J., Marin-Garcia, J.A.: A new formulation technique to model Materials and Operations Planning: the Generic Materials and Operations Planning (GMOP) Problem. European J. Industrial Engineering 7, 119–147 (2013)Mula, J., Maheut, J., Garcia-Sabater, J.P.: Supply Chain Network Design. Journal of Marketing and Operations Management Research 1, 378–383 (2012)Dudek, G., Stadtler, H.: Negotiation-based collaborative planning between supply chains partners. European Journal of Operational Research 163, 668–687 (2005)Torabi, S.A., Hassini, E.: Multi-site production planning integrating procurement and distribution plans in multi-echelon supply chains: an interactive fuzzy goal programming approach. International Journal of Production Research 47, 5475–5499 (2009)Kanyalkar, A.P., Adil, G.K.: Aggregate and detailed production planning integrating procurement and distribution plans in a multi-site environment. International Journal of Production Research 45, 5329–5353 (2007)de Kok, T.G., Fransoo, J.C.: Planning Supply Chain Operations: Definition and Comparison of Planning Concepts. In: Graves, S.C. (ed.) Handbooks in Operations Research and Management Science Supply Chain Management: Design, Coordination and Operation, vol. 11, pp. 597–675. Elsevier (2003)Buschkühl, L., Sahling, F., Helber, S., Tempelmeier, H.: Dynamic capacitated lot-sizing problems: a classification and review of solution approaches. OR Spectrum (2009)Maheut, J., Garcia-Sabater, J.P., Mula, J.: A supply Chain Operations Lot-Sizing and Scheduling Model with Alternative Operations. In: Sethi, S.P., Bogataj, M., Ros-McDonnell, L. (eds.) Proceedings of the Industrial Engineering: Innovative Networks, 5th International Conference on Industrial Engineering and Industrial Management "CIO 2011", Cartagena, Spain, pp. 309–316. Springer, London (2012)Garcia-Sabater, J.P., Maheut, J., Garcia-Sabater, J.J.: A two-stage sequential planning scheme for integrated operations planning and scheduling system using MILP: the case of an engine assembler. Flexible Services and Manufacturing Journal 24, 171–209 (2012)Pinto, J.M., Chen, P., Papageorgiou, L.G.: A discrete/continuous time MILP model for medium term planning of single stage multiproduct plants, pp. 1–6. Elsevier, B.V. (2007)Scheer, A.W.: Business Process Engineering - Reference Models for Industrial Enterprises. Springer (1994)Lin, J.T., Chen, T.L., Lin, Y.T.: Critical material planning for TFT-LCD production industry. International Journal of Production Economics 122, 639–655 (2009)Escudero, L.F.: CMIT, capacitated multi-level implosion tool. European Journal of Operational Research 76, 511–528 (1994)Maheut, J., Garcia-Sabater, J.P., Valero-Herrero, M.: MILP model for solving the supply chain operations scheduling problem with alternative operations considering delay penalization: a case study of a mass customization company. In: Proceedings of the 41st International Conference on Computers & Industrial Engineering, pp. 289–294 (2011

Hidratació i rendiment: pautes per a una elusió efectiva de la deshidratació per exercici

El rendiment de les capacitats físiques i mentals durant la pràctica esportiva o la competició, es troba disminuït sota condicions de deshidratació. La pèrdua de pes es deu a la pèrdua d’aigua (suor i respiració) i quan aquesta és important, afecta de manera decisiva els sistemes nerviós, cardiovascular, termoregulador, endocrí i/o metabòlic, i pot provocar fins i tot la mort. Per eludir aquests efectes negatius de la deshidratació així com la disminució del rendiment, l’atleta haurà de beure prou quantitat de líquid abans, durant, i després de la competició o la pràctica d’exercici. Idealment, la beguda serà una solució composta d’aigua, electròlits i carbohidrats, en quantitat adequada per garantir, d’una banda, un rendiment òptim durant la competició i, d’una altra, reposar eficaçment i completament les pèrdues hídriques, electrolítiques i energètiques. La composició i el volum de la beguda tindrà en compte els factors extrínsecs (temperatura, humitat, altitud, vent, etc.) que envolten la competició, els factors intrínsecs de l’atleta (nivell de deshidratació, problemes gastrointestinals, tipus de competició) i les pròpies característiques de la beguda (gust, temperatura, composició). En termes generals, els atletes no acostumen a beure, durant la pràctica esportiva, el volum necessari per reemplaçar la pèrdua de fluids i electròlits, cosa que fa que calgui establir pautes perquè ho facin. En aquest treball es presenten aquestes pautes i la base fisiològica que les sosté